A new regulator of osteoclastogenesis: Estrogen response element-binding protein in bone

Hydrogen sulfide: a new regulator of osteoclastogenesis?

The high mobility group protein 1 enhances binding of the estrogen receptor DNA binding domain to the estrogen response element.

We have examined the ability of the high-mobility group protein 1 (HMG1) to alter binding of the estrogen receptor DNA-binding domain (DBD) to the estrogen response element (ERE). HMG1 dramatically enhanced binding of purified, bacterially expressed DBD to the consensus vitellogenin A2 ERE in a dose-dependent manner. The ability of HMG1 to stabilize the DBD-ERE complex resulted in part from a d...

Mouse Estrogen Receptor b Forms Estrogen Response Element- Binding Heterodimers with Estrogen Receptor a

The recent discovery that an additional estrogen receptor subtype is present in various rat tissues has advanced our understanding of the mechanisms underlying estrogen signaling. Here we report on the cloning of the cDNA encoding the mouse homolog of estrogen receptor-b (ERb) and the functional characterization of mouse ERb protein. ERb is shown to have overlapping DNA-binding specificity with...

Characterization of a bone morphogenetic protein-responsive Smad-binding element.

Bone morphogenetic proteins (BMPs) are pleiotropic growth and differentiation factors belonging to the transforming growth factor-beta (TGF-beta) superfamily. Signals of the TGF-beta-like ligands are propagated to the nucleus through specific interaction of transmembrane serine/threonine kinase receptors and Smad proteins. GCCGnCGC has been suggested as a consensus binding sequence for Drosophi...

Cyclic AMP response element binding protein (CREB) in depression: A new role of an old molecule

Depression is one of the most common and most devastating psychiatric disorders. Despite its high prevalence and socio-economic impact, little is known about its etiology. Preclinical and clinical studies have demonstrated that depression can lead to cell loss and atrophy in limbic brain structures including hippocampus. An emerging hypothesis suggests that the treatment of depression is likely...